Interplay between Cdc2 Kinase and the c-Mos/MAPK Pathway between Metaphase I and Metaphase II in Xenopus Oocytes
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چکیده
منابع مشابه
Activation of Akt (protein kinase B) stimulates metaphase I to metaphase II transition in bovine oocytes.
In somatic cells, the serine/threonine kinase Akt (or protein kinase B) was shown to contribute to processes linked to cellular growth, cell survival and cell cycle regulation. In contrast to these findings, the function of Akt during the meiosis of mammalian oocytes remains to be investigated. We analysed the phosphorylation pattern and the activity of Akt during meiotic maturation (transition...
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Throughout oocyte maturation, and subsequently during the first mitotic cell cycle, the MAP kinase cascade and cyclin-B-Cdc2 kinase are associated with the control of cell cycle progression. Many roles have been directly or indirectly attributed to MAP kinase and its influence on cyclin-B-Cdc2 kinase in different model systems; yet a principle theme does not emerge from the published literature...
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15 صفحه اولSpindle and chromosomal alterations in metaphase II oocytes.
The spindle apparatus is a vital structure and must be structurally intact for proper segregation of the oocyte's genetic material during metaphase II. Endometriosis, oxidative stress, and cryopreservation can all adversely affect the structural integrity of the spindle, potentially resulting in aneuploidy and spontaneous abortion of the embryo. Advances in spindle imagery have made it possible...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2001
ISSN: 0012-1606
DOI: 10.1006/dbio.2000.0142